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Vol. 27, Issue 1, 98-101, January 1999

Detection of a Novel Cytochrome P-450 1A2 polymorphism (F21L) in Chinese

Jin-ding Huang, Wei-Chung Guo, Ming-Derg Lai, Yueleong Leon Guo, and George H. Lambert

Departments of Pharmacology (J.-d.H., W.-C.G.), Biochemistry (M.-D.L.), and Environmental and Occupational Health (Y.L.G.), College of Medicine, National Cheng Kung University, Tainan, Taiwan; and Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey (G.H.L.)

Despite a wide interindividual variation of cytochrome P-450 1A2 (CYP1A2) activity, genetic polymorphism of CYP1A2 has not been reported. By amplification of exons of CYP1A2 by polymerase chain reaction in eight Chinese subjects, the polymerase chain reaction products were directly sequenced. One subject showed heterozygous C2866right-arrowG (Phe21right-arrowLeu) polymorphism. DNA from 157 Chinese subjects (104 polychlorinated biphenyl-exposed subjects and 53 control subjects) was screened for polymorphism by single-strand conformation polymorphism method and MboII endonuclease digestion. Only 1 of 157 samples showed another heterozygous C2866right-arrowG mutation. The subject was previously exposed to polychlorinated biphenyl and showed a value of 3.5% in the caffeine breath test. The value is not significantly higher than the mean value of polychlorinated biphenyl-exposed subjects (3.12 ± 0.29%, mean ± S.E.M.). The incidence of the point mutation in these Chinese subjects is less than 1%. The prevalence of the F21L mutation in other ethnic groups and its effect on the metabolic activity of CYP1A2 remain to be further evaluated.

Copyright © 1999 by The American Society for Pharmacology and Experimental Therapeutics


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