Species and Sex Differences in Expression of Flavin-Containing Monooxygenase Form 3 in Liver and Kidney Microsomes

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

This Article

	Full Text
	Full Text (PDF)
	Submit a response
	Alert me when this article is cited
	Alert me when eLetters are posted
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ripp, S. L.
	Articles by Elfarra, A. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ripp, S. L.
	Articles by Elfarra, A. A.

Vol. 27, Issue 1, 46-52, January 1999

Species and Sex Differences in Expression of Flavin-Containing Monooxygenase Form 3 in Liver and Kidney Microsomes

Sharon L. Ripp, Kiyoshi Itagaki, Richard M. Philpot, and Adnan A. Elfarra

Department of Comparative Biosciences and Environmental Toxicology Center, University of Wisconsin-Madison (S.L.R., A.A.E.); and National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina (K.I., R.M.P.)

Flavin-containing monooxygenase (FMO) 3 is the predominant FMO isoform in adult human liver; however, little is known aboutits expression in common laboratory species. Studies have shownFMO3 levels to be sex-dependent in mouse liver, but not in humanliver. The current study was undertaken to determine the expressionof FMO3 in liver and kidney microsomes from multiple species,and to determine whether the sex dependence seen in mouse liverextends to other species and/or tissues. FMO3 had previously beenshown to be the major FMO involved in methionine S-oxidation inrat and rabbit liver microsomes. In this study, species differencesin FMO3 levels were assessed in liver microsomes from humans,rats, dogs, mice, and rabbits, and in kidney microsomes from rats,dogs, mice, and rabbits, by comparing methionine S-oxidase activities.Species differences were noted in male liver microsomes, withrabbits having 3-fold higher methionine S-oxidase activity thanmice and dogs and 1.5-fold higher activity than humans and rats.Species differences were also noted in male and female kidneymicrosomes, with rats exhibiting 2- to 6-fold higher methionineS-oxidase activity than the other species. Sex differences inFMO3 levels were assessed using methionine S-oxidase activityand immunoblotting, and were noted only in liver microsomes frommice and dogs, with females having higher levels than males. Resultsalso show that FMO3 orthologs from multiple species are catalyticallysimilar with regard to methionine, S-allyl-L-cysteine, and S-(1,2-dichlorovinyl)-L-cysteineS-oxidations.

This article has been cited by other articles:

R. M. Novick and A. A. Elfarra
Purification and Characterization of Flavin-Containing Monooxygenase Isoform 3 from Rat Kidney Microsomes
Drug Metab. Dispos., December 1, 2008; 36(12): 2468 - 2474.
[Abstract] [Full Text] [PDF]

J. T. Dever and A. A. Elfarra
L-Methionine-dl-sulfoxide Metabolism and Toxicity in Freshly Isolated Mouse Hepatocytes: Gender Differences and Inhibition with Aminooxyacetic Acid
Drug Metab. Dispos., November 1, 2008; 36(11): 2252 - 2260.
[Abstract] [Full Text] [PDF]

B. Kammerer, H. Scheible, W. Albrecht, C. H. Gleiter, and S. Laufer
Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor
Drug Metab. Dispos., June 1, 2007; 35(6): 875 - 883.
[Abstract] [Full Text] [PDF]

S. X. Hu, R. Soll, S. Yee, D. L. Lohse, A. Kousba, B. Zeng, X. Yu, A. McPherson, J. Renick, J. Cao, et al.
Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
Drug Metab. Dispos., June 1, 2007; 35(6): 929 - 936.
[Abstract] [Full Text] [PDF]

A. A. Elfarra and R. J. Krause
S-(1,2,2-Trichlorovinyl)-L-cysteine Sulfoxide, a Reactive Metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine Formed in Rat Liver and Kidney Microsomes, Is a Potent Nephrotoxicant
J. Pharmacol. Exp. Ther., June 1, 2007; 321(3): 1095 - 1101.
[Abstract] [Full Text] [PDF]

J. T. Dever and A. A. Elfarra
In Vivo Metabolism of L-Methionine in Mice: Evidence for Stereoselective Formation of Methionine-d-Sulfoxide and Quantitation of Other Major Metabolites
Drug Metab. Dispos., December 1, 2006; 34(12): 2036 - 2043.
[Abstract] [Full Text] [PDF]

C. Fu, L. Xi, Y. Wu, R. McCarter, A. Richardson, M. Hickey, and E.-S. Han
Hepatic Genes Altered in Expression by Food Restriction Are Not Influenced by the Low Plasma Glucose Level in Young Male GLUT4 Transgenic Mice
J. Nutr., November 1, 2004; 134(11): 2965 - 2974.
[Abstract] [Full Text] [PDF]

R. J. Krause, L. H. Lash, and A. A. Elfarra
Human Kidney Flavin-Containing Monooxygenases and Their Potential Roles in Cysteine S-Conjugate Metabolism and Nephrotoxicity
J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 185 - 191.
[Abstract] [Full Text] [PDF]

R. J. Krause, S. C. Glocke, and A. A. Elfarra
Sulfoxides as Urinary Metabolites of S-Allyl-L-Cysteine in Rats: Evidence for the Involvement of Flavin-Containing Monooxygenases
Drug Metab. Dispos., October 1, 2002; 30(10): 1137 - 1142.
[Abstract] [Full Text] [PDF]

A. T. El-Alfy and D. Schlenk
Effect of 17{beta}-Estradiol and Testosterone on the Expression of Flavin-Containing Monooxygenase and the Toxicity of Aldicarb to Japanese Medaka, Oryzias latipes
Toxicol. Sci., August 1, 2002; 68(2): 381 - 388.
[Abstract] [Full Text] [PDF]

V. Lattard, C. Longin-Sauvageon, J. Lachuer, P. Delatour, and E. Benoit
Cloning, Sequencing, and Tissue-Dependent Expression of Flavin-Containing Monooxygenase (FMO) 1 and FMO3 in the Dog
Drug Metab. Dispos., February 1, 2002; 30(2): 119 - 128.
[Abstract] [Full Text] [PDF]

L. H. Lash and J. C. Parker
Hepatic and Renal Toxicities Associated with Perchloroethylene
Pharmacol. Rev., May 11, 2001; (2001) 2.
[Abstract] [Full Text]

L. H. Lash, W. Qian, D. A. Putt, S. E. Hueni, A. A. Elfarra, R. J. Krause, and J. C. Parker
Renal and Hepatic Toxicity of Trichloroethylene and Its Glutathione-Derived Metabolites in Rats and Mice: Sex-, Species-, and Tissue-Dependent Differences
J. Pharmacol. Exp. Ther., April 1, 2001; 297(1): 155 - 164.
[Abstract] [Full Text]

W. Jacobsen, U. Christians, and L. Z. Benet
In Vitro Evaluation of the Disposition of A Novel Cysteine Protease Inhibitor
Drug Metab. Dispos., November 1, 2000; 28(11): 1343 - 1351.
[Abstract] [Full Text]

B. S. Cummings and L. H. Lash
Metabolism and Toxicity of Trichloroethylene and S-(1,2-Dichlorovinyl)-L-Cysteine in Freshly Isolated Human Proximal Tubular Cells
Toxicol. Sci., February 1, 2000; 53(2): 458 - 466.
[Abstract] [Full Text] [PDF]

L. H. Lash and J. C. Parker
Hepatic and Renal Toxicities Associated with Perchloroethylene
Pharmacol. Rev., June 1, 2001; 53(2): 177 - 208.
[Abstract] [Full Text] [PDF]

				J. T. Dever and A. A. Elfarra L-Methionine-dl-sulfoxide Metabolism and Toxicity in Freshly Isolated Mouse Hepatocytes: Gender Differences and Inhibition with Aminooxyacetic Acid Drug Metab. Dispos., November 1, 2008; 36(11): 2252 - 2260. [Abstract] [Full Text] [PDF]

				B. Kammerer, H. Scheible, W. Albrecht, C. H. Gleiter, and S. Laufer Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor Drug Metab. Dispos., June 1, 2007; 35(6): 875 - 883. [Abstract] [Full Text] [PDF]

				S. X. Hu, R. Soll, S. Yee, D. L. Lohse, A. Kousba, B. Zeng, X. Yu, A. McPherson, J. Renick, J. Cao, et al. Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine) Drug Metab. Dispos., June 1, 2007; 35(6): 929 - 936. [Abstract] [Full Text] [PDF]

				A. A. Elfarra and R. J. Krause S-(1,2,2-Trichlorovinyl)-L-cysteine Sulfoxide, a Reactive Metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine Formed in Rat Liver and Kidney Microsomes, Is a Potent Nephrotoxicant J. Pharmacol. Exp. Ther., June 1, 2007; 321(3): 1095 - 1101. [Abstract] [Full Text] [PDF]

				J. T. Dever and A. A. Elfarra In Vivo Metabolism of L-Methionine in Mice: Evidence for Stereoselective Formation of Methionine-d-Sulfoxide and Quantitation of Other Major Metabolites Drug Metab. Dispos., December 1, 2006; 34(12): 2036 - 2043. [Abstract] [Full Text] [PDF]

				C. Fu, L. Xi, Y. Wu, R. McCarter, A. Richardson, M. Hickey, and E.-S. Han Hepatic Genes Altered in Expression by Food Restriction Are Not Influenced by the Low Plasma Glucose Level in Young Male GLUT4 Transgenic Mice J. Nutr., November 1, 2004; 134(11): 2965 - 2974. [Abstract] [Full Text] [PDF]

				R. J. Krause, L. H. Lash, and A. A. Elfarra Human Kidney Flavin-Containing Monooxygenases and Their Potential Roles in Cysteine S-Conjugate Metabolism and Nephrotoxicity J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 185 - 191. [Abstract] [Full Text] [PDF]

				R. J. Krause, S. C. Glocke, and A. A. Elfarra Sulfoxides as Urinary Metabolites of S-Allyl-L-Cysteine in Rats: Evidence for the Involvement of Flavin-Containing Monooxygenases Drug Metab. Dispos., October 1, 2002; 30(10): 1137 - 1142. [Abstract] [Full Text] [PDF]

				A. T. El-Alfy and D. Schlenk Effect of 17{beta}-Estradiol and Testosterone on the Expression of Flavin-Containing Monooxygenase and the Toxicity of Aldicarb to Japanese Medaka, Oryzias latipes Toxicol. Sci., August 1, 2002; 68(2): 381 - 388. [Abstract] [Full Text] [PDF]

				V. Lattard, C. Longin-Sauvageon, J. Lachuer, P. Delatour, and E. Benoit Cloning, Sequencing, and Tissue-Dependent Expression of Flavin-Containing Monooxygenase (FMO) 1 and FMO3 in the Dog Drug Metab. Dispos., February 1, 2002; 30(2): 119 - 128. [Abstract] [Full Text] [PDF]

				L. H. Lash and J. C. Parker Hepatic and Renal Toxicities Associated with Perchloroethylene Pharmacol. Rev., May 11, 2001; (2001) 2. [Abstract] [Full Text]

				L. H. Lash, W. Qian, D. A. Putt, S. E. Hueni, A. A. Elfarra, R. J. Krause, and J. C. Parker Renal and Hepatic Toxicity of Trichloroethylene and Its Glutathione-Derived Metabolites in Rats and Mice: Sex-, Species-, and Tissue-Dependent Differences J. Pharmacol. Exp. Ther., April 1, 2001; 297(1): 155 - 164. [Abstract] [Full Text]

				W. Jacobsen, U. Christians, and L. Z. Benet In Vitro Evaluation of the Disposition of A Novel Cysteine Protease Inhibitor Drug Metab. Dispos., November 1, 2000; 28(11): 1343 - 1351. [Abstract] [Full Text]

				B. S. Cummings and L. H. Lash Metabolism and Toxicity of Trichloroethylene and S-(1,2-Dichlorovinyl)-L-Cysteine in Freshly Isolated Human Proximal Tubular Cells Toxicol. Sci., February 1, 2000; 53(2): 458 - 466. [Abstract] [Full Text] [PDF]