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Vol. 26, Issue 12, 1232-1240, December 1998

Physiological and Pathophysiological Regulation of Cytochrome P450

Edward T. Morgan, Marion B. Sewer, Heinrich Iber, Frank J. Gonzalez, Ying-Hue Lee, Robert H. Tukey, Steve Okino, Tien Vu, Yue-Hwa Chen, Jaspreet S. Sidhu, and Curtis J. Omiecinski

Department of Pharmacology, Emory University School of Medicine (E.T.M., M.B.S., H.I.), Laboratory of Metabolism, National Cancer Institute, National Institutes of Health (F.J.G., Y.-H.L.), Department of Pharmacology, University of California, San Diego (R.H.T., S.O., T.V., Y.-H.C), and Department of Environmental Health, University of Washington (J.S.S., C.J.O.)

This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology '98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.

Copyright © 1998 by The American Society for Pharmacology and Experimental Therapeutics


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Copyright © 1998 by the American Society for Pharmacology and Experimental Therapeutics.