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Vol. 26, Issue 10, 1039-1041, October 1998
Department of Pharmacology Extrahepatic glucuronidation, such as that in the central nervous
system (CNS), may play a very important role in xenobiotic disposition
and may serve to protect the CNS from potentially toxic xenobiotics.
UDP-glucuronosyltransferase (UGT) 1A6 is an important catalyst for
phenol and polycyclic aromatic hydrocarbon glucuronidation. Studies
were designed to determine the immunohistochemical localization of
UGT1A6 and the steroid-reactive UGTs 2B2 and 2B3 in brain regions
throughout the rat development. Neuronal cells, such as pyramidal
cells, in sections from cerebral cortex and hippocampus displayed
intensive UGT1A6-specific staining. UGT1A6-specific staining was also
found in neuronal cells throughout the cerebral cortex, as well as in
the cerebellar white matter. Glial cells revealed no apparent staining.
In addition, staining for UGT1A6 was seen in choroid plexus at a later
developmental stage. Although UGT1A6 staining was evident, brain
sections analyzed for UGT2B2 and UGT2B3 immunoreactivity showed no
significant staining. These results provide the first definitive
evidence for the presence and cellular localization of UGT1A6, in
neurons of developing rat brain, whereas UGT2B2 and UGT2B3 were not
detected.
University of Iowa College of
Medicine
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